What is NTFS TuneUp NTFS TuneUp - is a smart tool which allows you to manage the NTFS compression of your drives, it can be used as a replacement for the Microsoft Windows Disk CleanUp tool but certainly has more features, it is more customizable and does not freezes your PC. NTFS TuneUp features Let you choose between 3 optimization modes (both compression/decompression, compression only or decompression only)